Nanosponge Technology

Cellics Therapeutics technology platform offers
a revolutionary therapeutic approach for complex diseases.

Our technology strips cell membranes of their intracellular contents and create Nanosponges from these membranes to be leveraged as a therapeutic product. These Nanosponges are designed to counteract diverse disease pathologies by acting as biomimetic decoys to sequester and neutralize biological molecules that would otherwise attack host cells. Examples of such harmful agents include toxins, inflammatory cytokines and viruses. The cell membrane forming the outer layer of the Nanosponges is selected based on the disease pathology – specifically, which host cells are under attack. Nanosponges leverage the natural bioactivity of human cell membrane receptors for therapeutic efficacy. Featuring small size and large quantity, Nanosponges outcompete host cells to bind and sequester biological molecules.

Product development currently emphasizes using Nanosponges made of human red blood cell membrane and white blood cells for the treatment of bacterial infections and inflammatory diseases. A similar working principle can be applied with membranes of other cell types, making Nanosponges suitable for large and diverse disease areas. We have achieved proof of concept in animal models in a range of disease areas, as shown in the Full Pipeline.