Macrophage Nanosponge (MΦ-NS)
MΦ-NS are macrophage membrane nanoparticles.
Macrophages are a type of white blood cell of the immune system that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells. When macrophages are activated by foreign microorganisms such as bacteria and viruses that enter the human body, they release molecules known as cytokines, which can activate more macrophages and stimulate further immune response and cause inflammation. Severe virus or bacterial infections could cause macrophages to overrespond and cause serious systemic inflammation such as cytokine storm or sepsis. During the COVID-19 crisis, a lot of patients die of cytokine storms. As one macrophage can be made into tens of thousands of MΦ-NS, MΦ-NS can effectively absorb and neutralize inflammatory cytokines and control inflammation. In addition, MΦ-NS can also neutralize endotoxins from bacteria and certain viruses such as SARS-Cov-2, the culprit of COVID-19.
Given its versatility, MΦ-NS can be used in a wide range of infection and inflammatory diseases. The same IV formulation of MΦ-NS can be used to treat diseases such as Sepsis, Cytokine Release Syndrome (CRS), and COVID-19. The same toxicology program and Phase I clinical trial can be used in the development of these indications. Macrophage Nanosponge can also be made into oral, topical, or intraarticular formulation to treat inflammatory diseases such as Inflammatory Bowel Disease and Arthritis.
Current MΦ-NS Pipeline includes the following indications: