Cellular Nanoparticle (CNP) Drug Delivery Platform
We aim to address two of the biggest problems in drug delivery:
How do we efficiently get the therapeutic agent into the cell?
Cellics is pioneering the use of cell membrane-coated nanoparticles to increase the intracellular delivery efficiency of therapeutic agents, improving effectiveness and decreasing side effects. By utilizing engineered cell membranes that express viral fusion proteins to attach to the cell of interest, dramatically improved endosomal escape and increased expression of mRNA can be achieved.
This can be seen in the publication: mRNA nanomedicine: Design and recent applications
How do we target the desired tissue types?
Just like in our name, the basis of the CNP technology is the cell, and we use a lot of them. Our powerful assortment of cell membranes can be employed to create application specific CNPs. By leveraging specific cells or engineering our own, we can utilize the cells' surface proteins to target the tissues of interest. It is these same mechanisms that allow cells such as platelets to naturally gather at the cuts in our bodies. Through improved targeting, CNPs improve therapeutic effectiveness, lower drug load, and reduce side effects.
This can be seen in the publication: Drug Targeting via Platelet Membrane-Coated Nanoparticles